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FIGURE S.1. Characterizing the stability and Daunorubicin of Ligand Presentation Platform (LPP). A. Isometric view of LPP measuring 58 nm x 27 nm x 6 nm. B. LPP has a honey-comb lattice and has 20 overhangs on the bottom. C. Typical zoomed out TEM image of LPP. D. Image average of 15 images of LPP. E.b MgCl2 stability gel where lane L is 1kb ladder, FS is PEG-purified structure. Structures were PEG-purified and resuspended in varying concentrations of MgCl2 for 24hrs. Structures were then loaded in a 2% agarose gel. As shown LPP degrades at 1 mM MgCl2 . F. TEM images of LPP at 3, 1, and 0 mM MgCl2. G.Normalized gel intensity of LPP at varying MgCl2 concentrations. H. Fetal Bovine Serum (FBS) stability gel at room temperature (25OC). Structures were PEG-purified and resuspended in varying concentrations of FBS for 24hrs. Structures were then PEG-purified to remove nucleases and then loaded in a 2% agarose gel. I. TEM images of LPP at 20, 50, and 75 % FBS. J. Normalized gel intensity of [[Structure]] at varying FBS concentrations. K. Fetal Bovine Serum (FBS) stability gel at physiological temperature (37). Structures were PEG-purified and resuspended in varying concentrations of FBS for 24hrs. Structures were then PEG-purified to remove nucleases and then loaded in a 2% agarose gel. L. TEM images of LPP at 20, 50, 75 % FBS. M. Normalized gel intensity of LPP at varying FBS concentrations. N. Average Base Pair Binding Ratio (BBR) of LPP for 250 mM daunorubicin and varying concentrations of origami structure after 24hrs of incubation. 15 nM of LPP has the highest BBR. O. TEM images of 10nM, 15nM, and 20nM LPP after 24hr incubation. Note the twisted geometry of daunorubicin-incorporated structure versus daunorubicin-free structure. Scale Bars 100nm unless otherwise indicated.